Ukr.Biochem.J. 2016; Volume 88, Issue 4, Jul-Aug, pp. 57-65


QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts

M. M. Trush1*, V. V. Kovalishyn1, V. M. Blagodatnyi2, V. S. Brovarets1,
S. G. Pilyo1, V. M. Prokopenko1, D. M. Hodyna1, L. O. Metelytsia1

1Institute of Bioorganic Chemistry and Petrochemistry, National Academy
of Sciences of Ukraine, Kyiv;
2Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine;

The regression QSAR models were built to predict the antimicrobial activity of new thiazole derivatives. Compounds with high predicting activity were synthesized and evaluated against Gram-positive and Gram-negative bacteria and fungi. 1,3-Thiazole-4-ylphosphonium salts 4 and 5 displayed good antibacterial properties and high antifungal activity. The predictions are in a good agreement with the experiment results, which indicate the good predictive power of the created QSAR models.

Keywords: , ,


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