T. M. Horid’ko¹, H. V. Kosiakova¹, A. G. Berdyshev¹, O. F. Meged¹,
E. A. Gudz¹, O. V. Onopchenko¹, V. S. Asmolkova¹, V. M. Lozova²,
E. V. Tukalenko², O. V. Bondarenko², I. I. Tubalzeva²,
О. А. Kovalenko², M. Y. Makarchuk², N. M. Hula¹

¹Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
²ESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Ukraine;
e-mail: TanGoRi@ukr.net

The aim of this study was to evaluate the effects of N-stearoylethanolamine (NSE) on the number of biochemical parameters that are involved in the development of the stress response (corticosterone, catecholamines, testosterone, TBARS, nitric oxide, serotonin), memory state, exploratory activity and antinociceptive response in rats, using a model of chronic social stress. It has been demonstrated that administration of NSE (14 days , intragastrically, 50 mg/kg) after chronic social stress developed (stress was induced by daily agonistic interaction between animals), normalizes plasma content of corticosterone, testosterone, epinephrine, norepinephrine, dopamine, TBARS, nitrite-anion and  increases serotonin level  that leads to memory state improvement and increase in exploratory activity in rats. The tail-flick latency did not change, that is it remained at the level of stressed animals.

Keywords: catecholamines, chronic social stress, corticosterone, N-stearoylethanolamine, nitric oxide, serotonin, TBARS, testosterone