Ukr.Biochem.J. 2019; Volume 91, Issue 6, Nov-Dec, pp. 129-143
doi: https://doi.org/10.15407/ubj91.06.129
The contribution of the Nobel laureates to the study of lipid metabolism and its regulation. F. Lynen, K. Bloch, S. Bergström, B. Samuelsson, J. Vane, M. Brown, J. Goldstein
O. P. Matyshevska, V. M. Danilova, S. V. Komisarenko
Palladin Institute Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: matysh@yahoo.com
Received: 16 October 2019; Accepted: 18 October 2019
The aim of this work was to analyze the experimental achievements in the field of biochemical science, such as the structure and metabolism of lipids. Since the early 1960s, there has been a real breakthrough in the study of intermediate lipid metabolism and its regulation, which has been marked not only by the award of a number of Nobel Prizes, but also by the formation of clinical lipidology as a section of metabology. The discoveries made by Feodor Lynen and Konrad Bloch helped clarify the key role of cholesterol in the development of atherosclerosis and heart attacks. The discoveries of Sune Bergström and Bengt Samuelsson have given impetus to a number of studies on the biological functions of prostaglandins. Humanity should be grateful to English pharmacologist John Robert Vane for discovering prostacyclin and for the important role he played in understanding the ability of aspirin to block the production of prostaglandins from arachidonic acid. Joseph Goldstein and Michael Brown have made a fundamental contribution to the discovery of the mechanism of regulation of cholesterol metabolism in the body. They studied hypercholesterolemia, in particular a form of hereditary disease characterized by high levels of cholesterol and low-density lipoprotein (LDL) in the blood, in which atherosclerotic deposits are formed in the cells of the blood vessels. Thanks to fundamental research of all the above-mentioned nobelians, achievements in such fields as genetics of family hyperchesterolemia, regulation of the functional state of arteries and microvessels, prevention of atherosclerosis, and other vascular complications are generally recognized today.
Keywords: B. Samuelsson, F. Lynen, J. Vane, K. Bloch, lipid metabolism, M. Brown J. Goldstein, Nobel laureates, S. Bergström
References:
- Regime of access : http://nob-lit.ru/page.php?id=308
- Feodor Felix Konrad Lynen. Regime of access : https://uk.wikipedia.org/wiki/
- Vynogradova RP, Danilova VM, Komisarenko SV. Development on knowledge of hormone biochemistry in the works of the Nobel prize laureates of the first half of the 20th century: F. G. Banting, John J. R. Macleod, H. O. Wieland, A. O. Windaus, A. F. Butenandt, L. Ružička, E.Kendall, P. Hench, T. Reichstein. Ukr Biochem J. 2019; 91(3): 107-126. CrossRef
- Lyan NA. John Robert Vane. Allergol Immunol Pediatr. 2015; 4(43)): 4-8.
- Nobel Prize Laureates: Encyclopedia. Trans. from English M.: Progress, 1992
- Konrad Emil Bloch. Regime of access : https://uk.wikipedia.org/ wiki/
- Regime of access : https://indicator.ru/medicine/konrad-emil-blokh.htm.
- Konrad Emil Bloch. Regime of access : https://eleven.co.il/jews-in-world/science/10658/
- Konrad Bloch. Regime of access : http://n-t.ru/nl/mf/bloch.htm.
- List of Nobel laureates. Regime of access : https://uk.wikipedia.org/wiki/
- Sune Bergström. Regime of access : https://uk.wikipedia.org/wiki/
- Bergström Sune. Regime of access : http://n-t.ru/nl/mf/bergstrom.htm.
- Bergström Sune. Regime of access : http://journal.osnova.com.ua/article/6807.
- Bengt Samuelsson. Regime of access : https://uk.wikipedia.org/wiki/
- Regime of access : https://www.peoples.ru/science/biochemist/bengt_ingemar_samuelsson/
- Regime of access : https://www.nobelprize.org/prizes/medicine/1982/samuelsson/biographical
- Bengt Samuelsson. Regime of access : https://ru.wikipedia.org/wiki/
- Bengt Ingemar Samuelsson. Regime of access : https://en.wikipedia.org/wiki/
- Regime of access : https://www.nobelprize.org/prizes/medicine/1982/samuelsson/biographical/
- John Robert Vane. Regime of access : https://uk.wikipedia.org/wiki/
- Regime of access : https://www.nobelprize.org/nobel_prizes/medicine/laureates/1982/vane-autobio.html.
- Regime of access : https://ru.qwertyu.wiki/wiki/John_Vane.
- Regime of access : https://www.peoples.ru/medicine/john_robert_veyn/
- John Robert Vane. Regime of access : http://cyclowiki.org/wiki/
- Regime of access : http://garfield.library.upenn.edu/essays/v7p077y1984.pdf.
- Michael Stuart Brown. Regime of access : https://uk.wikipedia.org/wiki/
- Michael Stuart Brown. Regime of access : http://cyclowiki.org/wiki/
- Regime of access : https://ru.qwertyu.wiki/wiki/Michael_Stuart_Brown.
- Regime of access : https://eleven.co.il/jews-in-world/science/10736/
- Joseph Leonard Goldstein. Regime of access : https://uk.wikipedia.org/wiki/
- Joseph Leonard Goldstein. Regime of access : https://ru.qwertyu.wiki/wiki/
- Joseph Leonard Goldstein. Regime of access : https://ru.wikipedia.org/wiki/
- Regime of access : https://persons-info.com/persons/GOLDSTAIN_Dzhozef_Leonard.
