Ukr.Biochem.J. 2020; Volume 92, Issue 3, May-Jun, pp. 86-90

doi: https://doi.org/10.15407/ubj92.03.086

Men of the molecules

04.08.2020   Uncategorized   No comments

In memoriam of Prof. Russell Doolittle,
Prof. Eduard Lugovskoi and their friendship that outlive both of them

V. O. Chernyshenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: bio.cherv@gmail.com

Received: 02 July 2020; Accepted: 21 July 2020

In memoriam Eduard Lugovskoi and Russell Doolittle we are referring to several episodes of their life and work.  Russell Doolittle an American biochemist and his friend and colleague Ukrainian scientist Eduard Lugovskoi, both studied fibrinogen structure and functions and finally united their efforts in the revealing of the new mechanism of intramolecular interactions of fibrin molecule through coiled-coil region. The results of their common work and discussions were included to the article “The fibrin Bβ125-135 site is involved in the lateral association of protofibrils”. Valuable part of the communication dedicated to the poetry of Eduard Lugovskoi that inspired both of scientists in work and life. We are providing some remembrance of their collaboration, their letters sent to each other, fragments of handwriting and common photo of Russell Doolittle and Eduard Lugovskoi.

Keywords: , , , ,

References:

  1. Rocco M, Weisel JW, de Maat M. Professor Russell F. Doolittle (1931-2019). J Thromb Haemost. 2020; 18(1): 264-266. CrossRef
  2. Laudano AP, Doolittle RF. Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Biochemistry. 1980;19(5):1013-1019. PubMed, CrossRef
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  5. Lugovskoy EV, Gritsenko PG, Kapustianenko LG, Kolesnikova IN, Chernishov VI, Komisarenko SV. Functional role of Bbeta-chain N-terminal fragment in the fibrin polymerization process. FEBS J. 2007;274(17):4540-4549. PubMed, CrossRef
  6. Lugovskii EV, Kolesnikova IN, Platonova TN, Lugovskaia NE, Litvinova LM, Kostiuchenko EP, Chernyshenko TM, Ganova LA, Spivak N, Komisarenko SV.Simultaneous quantification of soluble fibrin and D-dimer in blood plasma for the assessment of the threat of thrombosis. Klin Med (Mosk). 2013;91(11):38-44. (In Russian). PubMed
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  8. Lugovskoi E. Fleetings. K.: Naukova Dumka, 2014. 248 p.
  9. From the letter of Russell Doolittle to Eduard Lugovskoi, 4th of May 2016. Here, and letters listed below, reprinted with the permission of Russell Doolittle.
  10. From the letter of Russell Doolittle to Eduard Lugovskoi, 13th of September 2017.
  11. Lugovskoi E. Momentum. K.: Naukova Dumka, 2018. 172 p.
  12. From the letter of Russell Doolittle to Eduard Lugovskoi, 27th of December 2016.
  13. Doolittle RF, Goldbaum DM, Doolittle LR. Designation of sequences involved in the “coiled-coil” interdomainal connections in fibrinogen: constructions of an atomic scale model. J Mol Biol. 1978;120(2):311-325. PubMed, CrossRef
  14. Lugovskoy EV, Gritsenko PG, Kolesnikova IN, Lugovskaya NE, Komisarenko SV. A neoantigenic determinant in coiled coil region of human fibrin beta-chain. Thromb Res. 2009;123(5):765-770. PubMed, CrossRef
  15. Lugovskoy EV, Kolesnikova IN, Komisarenko SV. Usage of monoclonal antibodies for determination of localization of antigenic determinants and fibrin polymerization sites within fibrinogen and fibrin molecules and their application in test-systems for diagnostics and the threat of thrombus formation. Biotechnologia Acta. 2013; 6(4): 33-42. CrossRef
  16. From the letter of Russell Doolittle to Eduard Lugovskoi, 12th of November 2010.
  17. From the letter of Russell Doolittle to Eduard Lugovskoi, 9th of October 2013.
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