Ukr.Biochem.J. 2020; Volume 92, Issue 5, Sep-Oct, pp. 161-165
doi: https://doi.org/10.15407/ubj92.05.161
A glance on the role of Hsien Wu in immunology development
Mohammad Ebrahimi
Department of History of Science and Scientific Archaeology,
University of Science and Technology of China, People’s Republic of China;
e-mail: ebrahimi@mail.ustc.edu.cn
Received: 13 April 2020; Accepted: 25 June 2020
Early in the 20th century, a number of researchers in the field of immunology investigated this science chemically. Immunochemistry is the study of antigens and antibodies and their chemical basis and resistance to disease, developed from immunology. The immunochemistry period began in 1918 and continued through the early 1960s. Since the beginning of the immunochemical period, many researchers have been working in the field of immunochemistry by introducing important immunohistochemical and immunocytochemical methods. Hsien Wu was inspired by the science of immunochemistry and was able to determine a method for the determination of hemoglobin. In this article, I attempt to illustrate Hsien’s achievements in this period by presenting Hsien Wu’s scientific biography and immunochemical history. Furthermore, providing documentary and scientific information on the course of immunochemistry and the role of Hsien in this course may be a spark for some researchers to explore the reasons for some of the chemical approaches and theories of this period.
Keywords: chemical approach, Hsien Wu, immunochemistry, immunology
References:
- Hsien Wu. Nutr Rev. 1974; 32(10): 319. CrossRef
- New York Times. (1959). DR. HSIEN. WU, 65, Blood Specialist; Biochemist, Co-Developer of Analysis Method, Is Deadw . Taught at U. of Alabama, p. 27. Retrieved from https://www.nytimes.com/1959/08/10/archives/d-r-hsien-wu-65-blood-specialist-biochemist-codeveloper-of-analysis.html
- Bishop C. Hsien Wu (1893–1959): A biographical sketch. Clin Chem. 1982; 28(2): 378-380. PubMed, CrossRef
- Zheng S. Hsien Wu, the founder of Chinese biochemistry and nutriology. Protein Cell. 2012;3(5):323-324. PubMed, PubMedCentral, CrossRef
- Edsall J. Hsien Wu and the First Theory of Protein Denaturation (1931). Adv Protein Chem. 1995; 46: 1-5. CrossRef
- Carmichael EB. Dr. Hsien Wu. Nature. 1960; 185(4716): 809-810. CrossRef
- Silverstein AM. The dynamics of conceptual change in twentieth century immunology. Cell Immunol. 1991; 132(2): 515-531. PubMed, CrossRef
- Rees A. The antibody molecule. Oxford: Oxford University Press, 2015. 364 p.
- Haurowitz F. The origin and development of immunochemistry (1890–1965). Trends Biochem Sci. 1979; 4(11): N268-N270. CrossRef
- Kabat EA, Mayer MM. Experimental immunochemistry. 1st ed. Charles Thomas Publisher. USA. 1948. 567 p.
- Heidelberger M, Kendall FE. The beginnings of quantitative immunochemistry. Trends Biochem Sci. 1979; 4(7): 168. CrossRef
- Orakpoghenor O, Avazi DO, Markus TP, Olaolu OS. A short review of immunochemistry. Immunogenet Open Access. 2018; 3(122): 2.
- Lin KH, Wu H, Chen TT. Effect of denaturation on digestibility of ovalbumin by pepsin and trypsin. Exp Biol Med. 1927; 25(3): 199-200.
- Wu H, Cheng LH, Li CP. Composition of Antigen-precipitin Precipitate. Exp Biol Med. 1928; 25(9): 853-855. CrossRef
This work is licensed under a Creative Commons Attribution 4.0 International License.