Ukr.Biochem.J. 2022; Volume 94, Issue 6, Nov-Dec, pp. 37-47

doi: https://doi.org/10.15407/ubj94.06.037

Agmatine, telomerase and trace minerals levels in patients with obstructive sleep apnea syndrome

13.02.2023   Uncategorized   No comments

D. Ülger*, S. Bakir, Ö. T. Doğan

Sivas Cumhuriyet University, Turkey;
*e-mail: dilaraulger@cumhuriyet.edu.tr

Received: 19 August 2022; Revised: 16 November 2022;
Accepted: 17 February 2023; Available on-line:  27 February 2023

Obstructive sleep apnea syndrome (OSAS) is a disease characterized by repetitive, partially or complete upper airway obstructions resulting in hypoxia and bioelectrical wakefulness reactions along with sleep. There is a limited and different information on the biochemical pathways that may determine harmful effects in OSAS patients with different disease severity. Hence, we aimed to estimate the plasma levels of polyamine agmatine, which has many effects on the central nervous system, telomerase and trace minerals in patients with OSAS. The study included 90 volunteer patients diagnosed with OSAS and divided into three groups of 30 people each according to the apnea-hypopnea index (AHI) score: mild, moderate and severe. Nocturnal blood oxygen saturation percentage (SpO2) and body mass index (BMI) were measured. Plasma agmatine level was defined by ultra-high-pressure liquid chromatography (UHPLC), plasma trace elements (Cu, Co, Mg, Mo, Zn, Se) level by inductively coupled plasma mass spectrometer (ICP-MS) and serum telomerase level by enzyme-linked immunosorbent assay (ELISA) method. It was found that SpO2 value decreased as the disease progressed and showed a negative correlation with BMI, Co and Se plasma levels. The levels of agmatine and telomerase were shown to lower in patients with severe OSAS group compared to other groups.

Keywords: , , , ,

References:

  1. Montesi SB, Bajwa EK, Malhotra A. Biomarkers of sleep apnea. Chest. 2012;142(1):239-245. PubMed, PubMedCentral, CrossRef
  2. Bagai K. Obstructive sleep apnea, stroke, and cardiovascular diseases. Neurologist. 2010;16(6):329-339. PubMed, CrossRef
  3. Krachler M, Irgolic KJ. The potential of inductively coupled plasma mass spectrometry (ICP-MS) for the simultaneous determination of trace elements in whole blood, plasma and serum. J Trace Elem Med Biol. 1999;13(3):157-169. PubMed, CrossRef
  4. Guo MR. Biochemistry of Human Milk/ Human Milk Biochemistry and Infant Formula Manufacturing Technology. 2nd ed. 2009; 299-337 p.
  5. Young VR. Trace element biology: the knowledge base and its application for the nutrition of individuals and populations. J Nutr. 2003;133(5 Suppl 1):1581S-1587S. PubMed, CrossRef
  6. Galea E, Regunathan S, Eliopoulos V, Feinstein DL, Reis DJ. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J. 1996;316(Pt 1):247-249. PubMed, PubMedCentral, CrossRef
  7. Zhao S, Wang B, Yuan H, Xiao D. Determination of agmatine in biological samples by capillary electrophoresis with optical fiber light-emitting-diode-induced fluorescence detection. J Chromatogr A. 2006;1123(1):138-141. PubMed, CrossRef
  8. Gumru S, Sahin C, Aricioglu F. A review on agmatine as a novel neurotransmitter/neuromodulator. Clin Exp Health Sci. 2014;3(5). (In Turkish). CrossRef
  9. Güzelgül F, Aksoy K. Telomeraz enziminin tanı ve tedavide kullanım alanı. Arşiv Kaynak Tarama Dergisi. 2010;20(2):69-88. (In Turkish).
  10. Boyer L, Audureau E, Margarit L Marcos E, Bizard E, Le Corvoisier P, Macquin-Mavier I, Derumeaux G, Damy T, Drouot X, Covali-Noroc A, Boczkowski J, Bastuji-Garin S, Adnot S. Telomere Shortening in Middle-Aged Men with Sleep-disordered Breathing. Ann Am Thorac Soc. 2016;13(7):1136-1143. PubMed, CrossRef
  11. Barceló A, Piérola J, López-Escribano H, de la Peña M, Soriano JB, Alonso-Fernández A, Ladaria A, Agustí A. Telomere shortening in sleep apnea syndrome. Respir Med. 2010;104(8):1225-1229. PubMed, CrossRef
  12. Increased plasma agmatine levels in patients with schizophrenia. J Psychiatr Res. 2013;47(8):1054-1060. PubMed, CrossRef
  13. Asker S, Asker M, Yeltekin AC, Aslan M, Demir H. Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications. Sleep Breath. 2015;19(2):547-552. PubMed, CrossRef
  14. Steinbrenner H, Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta. 2009;1790(11):1478-1485. PubMed, CrossRef
  15. Chen PC, Guo CH, Tseng CJ, Wang KC, Liu PJ. Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea. J Nutr Health Aging. 2013;17(8):639-644.PubMed, CrossRef
  16. Saruhan E, Sertoglu E, Unal Y, Bek S, Kutl G. The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea. Sleep Breath. 2021;25(2):923-930. PubMed, CrossRef
  17. Tinggi U. Selenium: its role as antioxidant in human health. Environ Health Prev Med. 2008;13(2):102-108. PubMed, PubMedCentral, CrossRef
  18. Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med. 2002;165(7):934-939. PubMed, CrossRef
  19. González-Montaña JR, Escalera-Valente F, Alonso AJ, Lomillos JM, Robles R, Alonso ME. Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update. Animals (Basel). 2020;10(10):1855. PubMed, PubMedCentral, CrossRef
  20. Sari SA, Ulger D, Ersan S, Bakir D, Uzun Cicek A, Ismailoglu F. Effects of agmatine, glutamate, arginine, and nitric oxide on executive functions in children with attention deficit hyperactivity disorder. J Neural Transm (Vienna). 2020;127(12):1675-1684. PubMed, CrossRef
  21. Jo I, Han C, Ahn Jo S, Seo JA, Par MH, Kim NH. Low levels of plasma agmatine in the metabolic syndrome. Metab Syndr Relat Disord. 2010;8(1):21-24. PubMed, CrossRef
  22. Gildeh N, Drakatos P, Higgins S, Rosenzweig I, Kent BD. Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer. J Thorac Dis. 2016;8(9):E901-E917. PubMed, PubMedCentral, CrossRef
  23. Wang WP, Iyo AH, Miguel-Hidalgo J, Regunathan S, Zhu MY. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res. 2006;1084(1):210-216. PubMed, PubMedCentral, CrossRef
  24. Fung SJ, Xi MC, Zhang JH, Sampogna S, Yamuy J, Morales FR, Chase MH. Apnea promotes glutamate-induced excitotoxicity in hippocampal neurons. Brain Res. 2007;1179:42-50. PubMed, PubMedCentral, CrossRef
  25. Feng Y, Piletz JE, Leblanc MH. Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2002;52(4):606-611. PubMed, CrossRef
  26. Bounhoure JP, Galinier M, Didier A, Leophonte P. Sleep apnea syndromes and cardiovascular disease. Bull Acad Natl Med. 2005;189(3):445-459. PubMed
  27. In E, Özdemir C, Kama D, Sökücü SN. Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome. Arch Bronconeumol. 2015;51(11):544-550. PubMed, CrossRef
  28. Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010;464(7288):520-528. PubMed, PubMedCentral, CrossRef
  29. Martynowicz H, Kornafel-Flak O, Urbanik D, Łaczmański Ł, Sobieszczańska M, Mazur G, Poręba R, Gać P. Coexistence of obstructive sleep apnea and telomerase activity, concentration of selected adipose tissue hormones and vascular endothelial function in patients with arterial hypertension. Respir Med. 2019;153:20-25. PubMed, CrossRef
  30. Tempaku PF, Mazzotti DR, Hirotsu C, Andersen ML, Xavier G, Maurya PK, Rizzo LB, Brietzke E, Belangero SI, Bittencourt L, Tufik S. The effect of the severity of obstructive sleep apnea syndrome on telomere length. Oncotarget. 2016;7(43):69216-69224. PubMed, PubMedCentral, CrossRef
Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.