Ukr.Biochem.J. 2025; Volume 97, Issue 1, Jan-Feb, pp. 75-79

doi: https://doi.org/10.15407/ubj97.01.075

Paralogism in the interpretation of thrombogram obtained with the thrombin generation assay of human blood plasma

26.02.2025   Uncategorized   No comments

Ye. M. Makogonenko1*, V. O. Chernyshenko1, V. Yu. Bardyk2,
А. V. Udovenko1, S. V. Komisarenko1

1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv,
2Taras Shevchenko National University of Kyiv, Ukraine;
*e-mail: ymakogonenko@gmail.com

Received: 12 November 2024; Revised: 22 January 2025;
Accepted: 21 February 2025; Available on-line: 03 March 2025

Recording thrombin generation in blood under the action of coagulation initiators provides important early information about the state of the hemostasis system. Thrombin generation analysis (TGA) developed to determine the endogenous clotting potential and anticoagulant activity of blood plasma is extremely important diagnostic and prognostic method. However, the main problem of the TGA method is that in the descending­ part of the thrombogram, an error appears in the conversion of thrombin activity to its concentration. By studying the temporal relationship between thrombin and plasmin activity, and clot structure during its formation and dissolution in human blood plasma we propose another option for calculating the parame­ters of the thrombogram obtained by the TGA method.

Keywords: , ,

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