Tag Archives: adiponectin
Chemerin-adiponectin axis in hypothyroidism
M. K. Najim1*, A. F. Al-Shukri2
1Department of Medical Laboratory Technology, College of Health and Medical Technology,
Al-Furat Al-Awsat Technical University, Kufa, Iraq;
Thi-Qar Health Directorate, Al-Rifae Teaching Hospital;
*e-mail: murtadha.najeem.chm@student.atu.edu.iq;
2Department of Medical Laboratory Technology, College of Health and Medical Technology,
Al-Furat Al-Awsat Technical University, Kufa, Iraq;
e-mail: kin.ebt@atu.edu.iq
Received: 09 April 2025; Revised: 30 June 2025;
Accepted: 12 September 2025; Available on-line: 17 September 2025
Hypothyroidism disrupts energy and metabolism due to insufficient thyroid hormones production, leading to metabolic disorders such as insulin resistance and dyslipidemia. Recent studies have demonstrated the impact of adipokines, chemerin and adiponectin on thyroid function. This review analyzes the involvement of these hormones in the metabolic and inflammatory complications of hypothyroidism, their effects and interactions through complex signaling pathways, as well as their possible contribution to the etiology and treatment of hypothyroidism, considering the importance of integrating biomarker data.
Diet-induced and age-related changes in rats: the impact of N-stearoylethanolamine intake on plasma lipoproteins, adiponectin, and adipocyte cholesterol-phospholipid composition
O. S. Tkachenko*, H. V. Kosiakova
Palladin Institute of Biochemistry,
National Academy of Sciences of Ukraine, Kyiv, Ukraine;
*e-mail: 888oksana.tkachenko@gmail.com
Received: 26 January 2024; Revised: 19 March 2024;
Accepted: 19 March 2024; Available on-line: 30 April 2024
Adiponectin is secreted by adipose tissue, associated with lipoprotein (LP) metabolism, down-regulated in insulin resistance states, and reduced in individuals suffering from obesity and cardiovascular diseases. Phospholipids and cholesterol are the main components of cell membranes and play a critical role in storage and secretory adipocyte functions. N-stearoylethanolamine (NSE) is a minor lipid affecting cell membrane lipids’ composition. Our study aimed to investigate plasma levels of adiponectin and cholesterol of low- and high-density LP (LDL and HDL) and adipocyte cholesterol-phospholipid (Chol-PL) composition of different age rats with high-fat diet (HFD)-induced obesity and insulin resistance and their changes under NSE administration. Our study demonstrated that chronic dietary fat overloading leads to obesity accompanied by impairment of glucose tolerance, a manifestation of dyslipidemia, and changes in plasma adiponectin levels in rats from two age groups (10-month-old and and 24-month-old). Prolonged HFD led to a reduction in plasma adiponectin levels and the growth of adipocyte cholesterol content in rats of different ages. A significant increase in plasma LDL-Chol level and main adipocyte PLs (phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and lysophosphatidylcholine) was observed in younger rats, whereas not detected in elder animals after dietary fats overloading. The decrease in the content of anionic phospholipids (phosphatidylinositol + phosphatidylserine) was also detected in 10-month-old HFD rats compared to the control animals. NSE administration positively affected the normalization of adiponectin levels in both age HFD groups. It significantly impacted the reduction of LDL-Chol levels and the growth of HDL-Chol concentration in the blood plasma of 10-month-old rats as well as PL-composition of young HFD rats and anionic PL restoring in 24-month-old rats. The positive effect on investigated parameters makes NSE a prospective agent for treating diet-induced and age-related metabolic disorders threatening cardiovascular diseases.
Correlation between adiponectin level and obesity as a risk factor for allergy disease
M. Spasovska1*, T. K. Panovska2
1General Hospital, Ohrid, R.Macedonia;
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Skopje, R. Macedonia;
*e-mail: spasovskamilena@yahoo.com
Received: 28 November 2021; Revised: 30 June 2022;
Accepted: 29 September 2022; Available on-line: 06 October 2022
Much research has focused on the connection between two inflammatory conditions, allergic reactions and obesity which has led to a focus on adiponectin, hormone with anti-inflammatory properties secreted by adipose tissue. The aim of this study was to determine the association of adiponectin with obesity, as a risk factor for the development of allergic condition in order to rationalize approach to its treatment. Research methods for inflammatory markers and biochemical parameters involve immunoassay technique. Statistical analysis was performed with Student’s t-test, Wilcoxon T-test and coefficient of correlation. The study included apparently healthy subjects and patients with allergy conditions with confirmed presence of specific IgE, classified into 2 groups according to their body mass index (BMI). The obtained data showed negative correlation (cor = – 0.6), between adiponectin levels and BMI values. Thus, decreased level of adiponectin is associated with increased BMI. The mean values of adiponectin in the studied population, with high statistical differences between the groups (19.1 ± 1.5; 17.7 ± 0.9), (18.8± 1.1; 16.6 ± 1.0) demonstrated the relationship between low adiponectin level and development of obesity, and what, in turn, increasd risk of developing allergic conditions. The assumption was made that adiponectin may be used as a sensitive biochemical marker for early diagnostics of allergic reactions.
Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPARγ gene expression in STZ-induced diabetic rat liver
B. Shahouzehi1, K. Barkhordari2, S. Aminizadeh3, Y. Masoumi-Ardakani4*
1Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Iran;
e-mail: bshahouzehi@yahoo.com;
2Department of Virology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran;
e-mail: khabatzanbil@gmail.com;
3Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Iran;
e-mail: soheilaminizadeh@gmail.com;
4Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Iran;
*e-mail: ymab125@yahoo.com
Diabetes is considered as a metabolic disease in which insulin secretion and functions are disturbed and characterized by hyperglycemia. L-carnitine is synthesized in most mammals and plays critical role in fatty acid oxidation and energy production. Data about the L-carnitine hypoglycemic effects are controversial. We evaluated long-term oral L-carnitine administration effects on blood glucose, insulin and adiponectin levels, as well as expression of AMPK, APPL1 and PPARγ genes in liver of STZ-induced diabetic rats. Group 1 (control), did not receive any treatment, group 2 received 50 mg/kg STZ by i.p injection, group 3 received single dose of 50 mg/kg STZ by i.p injection and also 600 mg/kg/day L-carnitine orally for 5 weeks. Our results showed that L-carnitine long-term oral supplementation significantly reduced blood glucose and normalized insulin levels in diabetic rats. Also, we found that L-carnitine significantly increased AMPK and APPL1 expression, and showed a mild elevation of PPARγ expression. In sum, we suggest that long-term L-carnitine supplementation has beneficial effects on diabetic rats which showed hypoglycemic effects. Probably the beneficial effects of L-carnitine are contributed to the upregulation of insulin sensitizers such as AMPK and adiponectin.