Tag Archives: dyslipidemia

Indicators of lipid metabolism disorders in the blood serum of adolescents with metabolic syndrome

L. A. Strashok1,2, O. V. Buznytska1,2*, О. М. Meshkova3

1Kharkіv Medical Academy of Postgraduate Education, Ukraine;
2V.N. Karazin Kharkіv National University, Ukraine;
3Bogomolets National Medical University, Kyiv, Ukraine;
*e-mail: ebuznickaa@ukr.net; elena.buznytska@gmail.com

Received: 16 April 2018; Accepted:13 November 2020

Atherogenic dyslipidemia is one of the main and early indication of adolescentrs with metabolic syndrome. Because there is not enough information about the nature of dyslipidemia in adolescents and the possibilities of its correction and prevention, the study of this problem is relevant. The goal of the study was to estimate the indexes of lipid metabolism in blood serum of adolescents with metabolic syndrome. We examined 200 obese patients aged 14–18 years, who were divided into two groups with and without metabolic syndrome. The control group consisted of 30 adolescents of similar age with normal body weight. The lipid profile of blood was studied by standardized methods using Cormay Multi semi-automatic photometer­. The level of β-lipoproteins in blood serum was determined by the turbidimetric method. Elevated levels of triglycerides, low and very low density lipoprotein cholesterol, β-lipoproteins and a tendency to decreased high density lipoprotein level cholesterol were found in the  blood serum of adolescents with metabolic syndrome  as the signs of atherogenic dyslipidemia. Reliable correlations both between the indexes of lipid profile and between atherogenic dyslipidemia indicators and anthropometric indexes were established, indicating an increased risk of lipid metabolic disturbances in individuals with abdominal obesity.

The impact of hydroxycitric acid on the lipid metabolism profile under experimental insulin resistance syndrome of Syrian hamsters

A. L. Zagayko, A. I. Shkapo, V. P. Fylymonenko, T. O. Briukhanova

National University of Pharmacy, Kharkiv, Ukraine;
e-mail: vpfylymonenko@gmail.com

The syndrome of insulin resistance (IR) is one of the leading reasons for the increased risk of cardiovascular diseases and their complications. Among the key components of IR are obesity and dyslipidemia. Hydroxycitric acid (HCA), an inhibitor of a key enzyme of lipogenesis ATP citrate lyase (ACLY) is a promising obesity treatment agent. The aim of this work was to investigate the effect of HCA on lipid and lipoproteins content in the blood serum, as well as lipid content and activity of some lipid metabolism enzymes in the liver of hamsters with IR. IR was modeled by keeping animals on high-fat diet with addition of fructose. Lipid content was determined by using standard reagent kits, the level of lipoproteins, the activity of glucose 6-phosphate dehydrogenase and ACLY – spectrophotometrically, lysosomal lipase activity – fluorimetrically. Development of hyperlipidemia and atherogenic dyslipidemia, lipid accumulation in the liver, activation of lysosomal lipase and ACLY and reduction of glucose 6-phosphate dehydrogenase activity were shown under IR. The treatment by HCA reduces the manifestations of hyperlipidemia, but enhances the lipid accumulation in the liver.