Ukr.Biochem.J. 2020; Volume 92, Issue 6, Nov-Dec, pp. 183-198


The discovery of the DNA double helix, or the revolution that ushered in the era of molecular biology (Nobel Prize 1962)

O. P. Matyshevska*, V. M. Danilova, S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiyv;

Received: 19 June 2020; Accepted: 13 November 2020

The 1950s were marked by groundbreaking discoveries in the research of the molecular structure of DNA. The chronology of awarding Nobel Prizes to the authors of these discoveries, did not always coincide with the chronology of announcing the results of their research. J. Watson and F. Crick published their short paper on the discovery of DNA structure, which rocked the scientific world, in Nature in 1953, but received the Nobel Prize together with M. Wilkins only 9 years later. The discovery of the DNA chemical structure is recognized as one of the greatest biological discoveries of the twentieth century. This landmark scientific breakthrough began the development of a new field of the life sciences: molecular biology.

Keywords: , , , , , , ,


  1. The Nobel Prize in Physiology or Medicine 1962. Regime of access:
  2. By David Ewing Duncan, July 1, 2003. Regime of access:
  3. James Watson. Regime of access:
  4. Danylova TV, Komisarenko SV. Nobel prize winner Erwin Schrödinger: the physicist, philosopher, and godfather of molecular biology and genetics. Ukr Biochem J. 2020; 92(3): 93-100.  CrossRef
  5. Regime of access:
  6. Danylova TV, Komisarenko SV. Standing on the shoulders of giants: James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin and the birth of molecular biology. Ukr Biochem J. 2020; 92(4): 154-165. CrossRef
  7. Danilova VM, Vynogradova RP, Komisarenko SV. The contribution of Nobel prize laureates to research of the protein structure: J. Sumner, J. Northrop, W. Stanley, L. Pauling, F. Sanger, M. Perutz, J. Kendrew. Ukr Biochem J. 2020;92(4):127-153. CrossRef
  8. Franklin RE, Gosling RG. Molecular configuration in sodium thymonucleate. Nature. 1953;171(4356):740-741. PubMed, CrossRef
  9. Watson JD, Crick FH. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature. 1953;171(4356):737-738. PubMed, CrossRef
  10.  Wilkins MHF, Stokes AR, Wilson HR. Molecular structure of deoxypentose nucleic acids. Nature. 1953;171(4356):738-740. PubMed, CrossRef
  11. Watson JD, Crick FH. Genetical implications of the structure of deoxyribonucleic acid. Nature. 1953;171(4361):964-967. PubMed, CrossRef
  12. Watson JD. Molecular Gene Biology. Trans. from English.  Ed.  V.A. Engelhardt.  M.: Mir, 1978. 706 p.
  13. Watson JD. The double helix: a personal account of the discovery of the structure of DNA. New York: Atheneum, 1968. 226 p.
  14. Cold_Spring_Harbor_Laboratory. Regime of access:
  15. Sample Ian. DNA pioneer James Watson sets out radical theory for range of diseases. The Guardian. (28 February 2014).
  16. James Dewey Watson. Avoid boring people. Trans, from English. Corpus, 2010. 463 с.
  17. James Watson. Regime of access : Watson.
  18.  Regime of access :
  19. Crick Francis. Regime of access : Francis.
  20. Crick F.  The double helix: a personal view. Nature. 1974;248(5451):766-769.  PubMed, CrossRef
  21. Samyn D. One hundred great scientific discoveries. Secrets of the living: DNA.  Regime of access :
  22. Crick FH. On protein synthesis. Symp Soc Exp Biol. 1958;12:138-163. PubMed
  23. Crick FH, Barnett L, Brenner S, Watts-Tobin RJ. General nature of the genetic code for proteins. Nature. 1961;192(4809):1227-1232.
    PubMed, CrossRef
  24. Crick F. Central dogma of molecular biology. Nature. 1970;227(5258):561-563. PubMed, CrossRef
  25. Crick FH.  The Croonian lecture, 1966. The genetic code. Proc R Soc Lond B Biol Sci. 1967;167(1009):331-347. PubMed, CrossRef
  26. Crick FH. Life Itself: Its Origin and Nature. Simon and Schust, 1982.
  27. Crick F. H. What Mad Pursuit: A Personal View of Scientific Discovery: Basic Books reprint edition, 1990.
  28. Crick F, Koch C. Towards a neurobiological theory of consciousness. Neurosciences. 1990;2:263-275.
  29. Wilkins Maurice. Regime of access:
  30. Wilkins M. The Third Man of the Double Helix: An Autobiography.  Oxford: OUP, 2005. 314 p.
  31. Wilkins MHF. Nobel Lecture: The molecular configuration of nucleic acids. Regime of access :
  32. Klug A. The discovery of the DNA double helix. J Mol Biol. 2004;335(1):3-26. PubMed, CrossRef

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