Ukr.Biochem.J. 2021; Volume 93, Issue 4, Jul-Aug, pp. 111-119

doi: doi: https://doi.org/10.15407/ubj93.04.111

The discovery of genetic control of enzyme and virus synthesis: 1965 Nobel Prize Laureates André Lwoff, François Jacob, Jacques Monod

O. P. Matyshevska, V. M. Danilova, S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiyv;
e-mail: matysh@yahoo.com

Received: 19 April 2021; Accepted: 07 July 2021

The middle of the 20th century was marked by a number of significant events in molecular biology, among which the groundbreaking discovery of the double helix of DNA, which could self-replicate and thus perform the main life function; the isolation of enzymes for DNA synthesis, and DNA synthesis outside the cell, to name but a few. However, the question of how the information transmission from DNA to proteins is regulated remained open. The concept of the mechanism of regulation of prokaryotic gene activity developed by three French scientists (André Lwoff, François Jacob, Jacques Monod; Nobel Prize 1965), which was a logical outcome of the research in genetics and biochemistry over the previous decades, is recognized to be one of the remarkable achievements in molecular biology. This article describes the essence of the discovery of Lwoff, Jacob and Mono that is the identification of two different groups of genes – structural and functional – and the role that these genes perform in the transmission of genetic information.

Keywords: , , , , ,


References:

  1. Danylova TV, Komisarenko SV. Standing on the shoulders of giants: James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin and the birth of molecular biology. Ukr Biochem J. 2020;92(4):154-165. CrossRef
  2. Matyshevska OP, Danilova VM, Komisarenko SV. The discovery of the DNA double helix, or the revolution that ushered in the era of molecular biology (Nobel Prize 1962). Ukr Biochem J. 2020;92(6):183-198. CrossRef
  3. Matyshevska OP, Danilova VM, Komisarenko SV. The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg. Ukr Biochem J. 2021;93(1):129-138. CrossRef
  4. Regime of access :  https://www.nobelprize.org/prizes/medicine/1965/ceremony-speech/
  5. André Lwoff. Regime of access : https://uk.wikipedia.org/wiki
  6. André Lwoff. Biographical. Regime of access :  https://www.nobelprize.org/prizes/medicine/1965/lwoff/biographical/
  7. Danilova VM, Vynogradova RP, Komisarenko SV. The contribution of the Nobel Prize laureates to the development of dynamic biochemistry and bioenergetics. E. Buchner, A. Kossel, R. Willstätter, O. Meyerhof, A. Hill, O. Warburg, A. Szent-Györgyi. Ukr Biochem J. 2019;91(1):108-126. CrossRef
  8. Jacques Monod – Biographical. NobelPrize.org. Nobel Media AB 2021. Wed. 24 Feb 2021.  https://www.nobelprize.org/prizes/medicine/1965/monod/biographical/
  9. Jacques Monod. Regime of access : https://www.nobelprize.org/nobel_prizes/medicine/laureates/1965/monod-lecture.pdf
  10. Lysogenia. Pharmaceutical encyclopedia. Regime of access : https://www.pharmencyclopedia.com.ua.
  11. Jacob François. The statue within: an autobiography. Basic books, New York, 1988.
  12. François Jacob. Regime of access : https://www.nobelprize.org/nobel_prizes/medicine/laureates/1965/jacob-lecture.pdf
  13. Watson JD. RoLe of RNA in the synthesis of proteins. Biofizika. 1963;8:401-416. (In Russian). PubMed
  14. Regime of access : https://www.nobelprize.org/prizes/medicine/1965/summary/.
  15. Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961;3(3):318-356. PubMed, CrossRef
  16. André Lwoff. Interaction among Virus, Cell, and Organism. Nobel Lecture, December 11, 1965.
  17. Nobel laureates: André Lwoff. Regime of access : https://indicator.ru/biology/nobelevskie-laureaty-andre-lvov.htm.
  18. Jacques Lucien Monod, 9 February 1910 – 31 May 1976. Biogr Mem Fellows R Soc. 1977;23:384-412. CrossRef
  19. Jacques Monod. Nobel Prize in Medicine 1965. Regime of access : http://www.nobeliat.ru/laureat.php?id=312
  20. Jacques Monod. Le hasard et la nécessité. Paris, Editions du Seuil, 1970.
  21. Jacob François. La logique du vivant. Une histoire de l’hérédité. Paris, Éd. Gallimard, 1970.

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