Tag Archives: creatinine

Antioxidative effect of the N-stearoylethanolamine in the heart tissue and blood plasma of rats under doxorubicin treatment

I. A. Goudz, N. M. Gula, T. O. Khmel, T. M. Goridko, A. G. Berdyshev

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: ngula@biochem.kiev.ua

The influence of N-stearoylethanolamine on the alterated antioxidant enzyme activity in the heart tissue and blood plasma of rats under the doxorubicin treatment was investigated.  It was shown that doxorubicin administration caused the decrease of antioxidant enzymes activity (superoxide dismutase and glutathione peroxidase) in the heart tissue. Administration of the NSE promoted the partial normalization of these enzymes activity. It was shown that doxorubicin treatment caused the increase of the urea and creatinine level in the blood plasma of experimental animals.  The NSE administration normalized the level of the urea and did not affect creatinine level.

Comparison of blood biochemical indices in rats exposed to lead in macrodispersed form and nanoform

 I. A. Lazarenko, N. M. Melnikova

National University of Life and Environmental Sciences of Ukraine, Kyiv;
e-mail: ilazarenko2009@yandex.ru

It is shown that the increasing content of lead in blood (6.3 and 3.7 times) and liver (30.1 and 4.6 times) in rats after 14-days per os exposure both to lead acetate (macrodispersed form) and lead nanoparticles (nanoform) in a dose of 7 mg/100 g of body weight leads to the increased of activity of blood enzymes: alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase and a decrease of creatinine level. Lead in nanoform with slight accumulation, due to the greater elimination, expressed higher biological activity and reactivity as compared to macrodispersed form. Thus the exposure to lead in different dispersed form suggests metabolic disorders in rats, and accumulation of lead and biochemical changes are more expressed in the liver.

Biochemical changes in rats under the influence of cesium chloride

N. M. Melnikova, O. V. Yermishev

National University of Life and Environmental Sciences of Ukraine, Kyiv;
e-mail: iermishev@i.ua

Cesium is lately accumulated actively in the environment, but its influence on human and ani­mal organism is the least studied among heavy metals. It is shown that the action of cesium chloride in rats caused significant changes in blood chemistry, which are characterized by a decrease of total protein content, pH, an increase in the level of urea, creatinine, glucose and total hemoglobin. The results showed that potassium content in all the studied organs and tissues of poisoned rats decreases under the action of cesium chloride. Histological examination of the heart tissue in rats poisoned with cesium chloride indicates the onset of pathology of cardiovascular system. It was found out that use of the drug “Asparkam” reduces the negative effect of cesium chloride on the body of rats.