Ukr.Biochem.J. 2013; Volume 85, Issue 2, Mar-Apr, pp. 105-109

doi: http://dx.doi.org/10.15407/ubj85.02.105

Biochemical changes in rats under the influence of cesium chloride

N. M. Melnikova, O. V. Yermishev

National University of Life and Environmental Sciences of Ukraine, Kyiv;
e-mail: iermishev@i.ua

Cesium is lately accumulated actively in the environment, but its influence on human and ani­mal organism is the least studied among heavy metals. It is shown that the action of cesium chloride in rats caused significant changes in blood chemistry, which are characterized by a decrease of total protein content, pH, an increase in the level of urea, creatinine, glucose and total hemoglobin. The results showed that potassium content in all the studied organs and tissues of poisoned rats decreases under the action of cesium chloride. Histological examination of the heart tissue in rats poisoned with cesium chloride indicates the onset of pathology of cardiovascular system. It was found out that use of the drug “Asparkam” reduces the negative effect of cesium chloride on the body of rats.

Keywords: , , , , , , , , ,


References:

  1. Vlasyk LI. Peculiarities of kidneys functional status in old rats under action of iodide cesium. Sovremennye Problemy Tokcikologii. 1999;(1):30-33.
  2. Klikh LV, Melnichuk DO, Melnikova NM. Cs accumulation depending on the acid-base blood status. Visnyk Agrarnoi Nauky. Agrovisnyk. 2008;(7):30-33.
  3. Shulzhenko VS, Khatkevich AN, Kapelko VI. Pathological Physiology and Experimental Therapy. Moscow: Meditsina. 1988.  P. 15-19.
  4. Bruk MM. The mechanism of action of the stable cesium isotope compounds on blood circulation in experiment / Sbornik nauchnykh trudov. Kharkov Med. Inst.  Kharkov, 1969;(Is. 87):106-113.
  5. Kolesnikov VA. Heavy metals influence on biochemical reactions. Vestnik KSAU. 2009;(5):106-111.
  6. Vadzyuk OB, Chunikhin OYu, Kosterin SO. Effect of mitochondrial ATP-dependent potassium channel effectors diazoxide and glybenclamide on hydrodynamic diameter and membrane potential of the myometrial mitochondria. Ukr Biokhim Zhurn. 2010 Jul-Aug;82(4):40-7. Ukrainian. PubMed
  7. Gutnikova AR, Makhmudov KO, Saidkhanov BA, Tadzhikulova OD, Ergashev NA, Asrarov MI, Kosnikova IV. About membranotropic action of heavy metal salts and basic ways of its correction. Toxicol Review. 2009;(3):21-26.
  8. Axelrod LB, Arshinova LS, Gaidenko AI. Comparative estimation of cardiotropic effects of nicamag, panangin, asparkam. Pharmacol Toxicol. 1985;48(5):51-55.
  9. Korzhevsky D. E. Giliarov A.V. Basics of histologic techniques. St. Petersburg: Spets. Lit., 2010. 95 p.
  10. Kushkevych IV, Hnatush SO, Mutenko HB. Glutathione level of Desulfovibrio desulfuricans IMV K-6 under the influence of heavy metal salts. Ukr Biokhim Zhurn. 2011 Nov-Dec;83(6):104-9. PubMed
  11. Paranyak RP, Vasyltseva  LP, Makukh K. Pathways of heavy metals entrance to environment and their effects on living organisms.  Animal Biology. 2007;9(1-2):83-89.
  12. Trakhtenberg IM, Kolesnikov VS, Lukovenko VP. Heavy Metals in the Environment: Modern Hygienic and Toxicological Aspects. Minsk: Nauka i Tekhnika, 1999. 285 p.
  13. Toxicological profile for cesium / U. S. Dеpart­ment of health and human service. Public Health Servise Agensy for Toxic Substanses and Diasease Registry. Atlanta, Georgia. 2004. 306 р.
  14. Mel’nichuk DA. Metabolic system of acid-base homeostasis in the human and animal body. Ukr Biokhim Zhurn. 1989 May-Jun;61(3):3-21. Russian. PubMed
  15. Derkach EA, Shepeleva IA. The concentration of the macro- and microelements in rabbit blood upon strontium chloride poisoning. Ukr Biokhim Zhurn. 2010;82(4, Suppl. 2):245-246.
  16. Sato T, Sasaki N, O’Rourke B, Marbán E. Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J Am Coll Cardiol. 2000 Feb;35(2):514-8. PubMedCrossRef
  17. Drichko VF. Discrimination of alkaline elements by different tissues in rats on diet with normal and elevated levels of cesium. Aftoref. dis. … kand. biol. nauk. L., 1972.  17 p.

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.