Tag Archives: triglycerides
Lipid parameters in the blood of coronary artery diseases patients depending on age and dietary components: a case study
S. Prasad1, M. K. Mishra2*, A. K. Yadav2
1Department of Biochemistry, K. J. Somaiya Medical College and Research Mumbai, India;
2Department of Biochemistry, Shri Ramakrishna Institute of Medical Science
and Sanaka Hospitals, Durgapur, West Bengal, India;
*e-mail: mritunjaymishra007@gmail.com
Received: 19 March 2022; Revised: 13 September 2022;
Accepted: 04 November 2022; Available on-line: 14 November 2022
Coronary artery disease (CAD) is the major cause of mortality worldwide and is defined as an elevated level of atherogenic cholesterol and low levels of HDL cholesterol. However, very few studies have been conducted in India on the association of blood lipid profile with age and diet. The study aims to estimate lipid parameters in the blood of CAD patients aged 40-70 years on different diets. Lipid parameters were analyzed by enzymatic method on EM-200 fully automated Biochemistry analyzer. The data obtained showed that the majority of patients who suffered from CAD were between the age group of 51-60 years. Patients with CAD had altered lipid profiles, with higher levels of serum TGs, total cholesterol and low levels of HDL. Vegetarians have been found to have reduced lipid risk factors for coronary heart disease compared to patients on a mixed diet.
Hypoglycemic and hypolipidemic effects of Corchorus olitorius leaves as a food supplement on rats with alloxan-induced diabet
G. N. Anyasor, O. O. Adekanye, O. T. Adeyemi, O. Osilesi
Department of Biochemistry, Benjamin S. Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria;
e-mail: olaoluwatemi@yahoo.com
Received: 16 October 2019; Accepted: 15 May 2020
Corchorus olitorius is a species of shrub in the family Malvaceae known to have rich sources of chemical compound. The leaves of this plant are locally consumed as a vegetable and as a remedy in Africa, Middle East and Southern Asia. This study was designed to evaluate the hypoglycemic and hypolipidemic effects of C. olitorius leaves sample given for 14 days as a food supplement to rats with alloxan-induced diabet. Twenty one male albino rats weighing 150-200 g were randomly assigned into three groups: 1 – control rats; 2 – diabetic rats; 3 – diabetic rats fed with C. olitorius leaves as supplement. Phytochemical analysis of C. olitorius leaves ethanolic extract revealed the presence of alkaloids, anthraquinone, cardiac glycosides, saponins, tannins, phenols, phlobatannins and flavonoids. Diabetic rats fed with C. olitorius leaves as a supplement were shown to have significantly (P < 0.01) decreased plasma glucose, LDL-cholesterol, total cholesterol and triglycerides levels when compared with untreated diabetic rats. The findings from this study indicated that C. olitorius leaf possesses hypoglycemic and hypolipidemic properties.
Corvitin modulates the content of lipids in rat liver bile
T. V. Vovkun1, P. I. Yanchuk1, L. Ya. Shtanova1,
S. P. Veselsky1, N. B. Filimonova1, I. V. Komarov2
1ESC “Institute of Biology and Мedicine”, National Taras Shevchenko University of Kyiv, Ukraine
2“Institute of High Technologies”, National Taras Shevchenko University of Kyiv, Ukraine;
e-mail: shtanova@ukr.net
Received: 23 March 2019; Accepted: 18 October 2019
Quercetin (QUE) and its water-soluble form сorvitin are medicinally important members of the flavonoid family and the most prominent dietary antioxidants. Numerous pharmacological effects of quercetin include protection against diseases, such as atherosclerosis, myocardial infarction, and cerebrovascular diseases. Corvitin modulates liver blood flow but its effects on liver lipid metabolism have not been understood. We investigated the influence of corvitin (2.5, 5, 10 mg/kg) on the formation and secretion of cholesterol (Chol), cholesterol esters (EChol), phospholipids (PLs), free fatty acids (FFAs), and triglycerides (TGs) into the bile. Secreted bile was collected during 2.5 h of the experiment. Lipid fractions of the bile were separated by thin-layer chromatography. We defined that administration of corvitin caused a significant (P < 0.05–0.001) increase in levels of all studied lipid components of bile. At a dose of 2.5 and 5 mg/kg corvitin increased bile content of Chol, PLs and FFAs,and at a dose of 10 mg/kg had the largest effect on the total production of EChol and TGs. We concluded that corvitin activates the liver lipids metabolism and processes of bile formation.