Ukr.Biochem.J. 2020; Volume 92, Issue 4, Jul-Aug, pp. 63-69


Hypoglycemic and hypolipidemic effects of Corchorus olitorius leaves as a food supplement on rats with alloxan-induced diabet

G. N. Anyasor, O. O. Adekanye, O. T. Adeyemi, O. Osilesi

Department of Biochemistry, Benjamin S. Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria;

Received: 16 October 2019; Accepted: 15 May 2020

Corchorus olitorius is a species of shrub in the family Malvaceae known to have rich sources of chemical compound. The leaves of this plant are locally consumed as a vegetable and as a remedy in Africa, Middle East and Southern Asia. This study was designed to evaluate the hypoglycemic and hypolipidemic effects of C. olitorius leaves sample given for 14 days as a food supplement to rats with alloxan-induced diabet. Twenty one male albino rats weighing 150-200 g were randomly assigned into three groups: 1 – control rats; 2 –  diabetic rats; 3 – diabetic rats fed with C. olitorius leaves as supplement. Phytochemical analysis of C. olitorius leaves ethanolic extract revealed the presence of alkaloids, anthraquinone, cardiac glycosides, saponins, tannins, phenols, phlobatannins and flavonoids. Diabetic rats fed with C. olitorius leaves as a supplement were shown to have significantly (P < 0.01) decreased plasma glucose, LDL-cholesterol, total cholesterol and triglycerides levels when compared with untreated diabetic rats. The findings from this study indicated that C. olitorius leaf possesses hypoglycemic and hypolipidemic properties.

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  1. Velempini P, Riddoch I, Batisani N. Seed treatments for enhancing germination in wild okra (Corchorus olitorius). Exp Agric. 2003;39(4):441-447. CrossRef
  2. Adegoke AA, Adebayo-Tayo BC. Phytochemical composition and antimicrobial effects of Corchorous olitorius leaf extracts on four bacterial isolates. J Med Plant Res. 2009;3(3):155-159.
  3. Mahbubul MI. Biochemistry, medicinal and food values of Jute (Corchorus capsularis L. and C. olitorius L.) leaf: a review. Int J Enhanced Res Sci Technol Eng. 2013;2(11):35-44.
  4. Abdul S, Kaushik C. Jute-A biological elixir with multifaceted applications: An overview. Int J Res Pharm Sc. 2015; 6(4): 323-332.
  5. Wadkar KA, Magdun CS, Patil SS, Naikwade NS. Anti-diabetic potential and Indian medicinal plants. J Herbal Med Toxicol. 2008; 2(1): 45-50.
  6. Yakubu MT, Akanji MA, Nafiu MO. Anti-diabetic activity of aqueous extract of Cochlospermum planchonii root in alloxan-induced diabetic rats. Cameroon J Exp Biol. 2010;6(2):91-100. CrossRef
  7. Trease GE, Evans WC. Pharmacognosy: a Physician’s Guide to Herbal Medicine. 13th ed. London: Bailliere Tindall, 1989. P. 176-180.
  8. Harbone JB. Phytochemical Methods. A Guide to Modern Technique of Plant Analysis. London: Chapman and Hall Ltd., 1973. P. 49-188.
  9. Sofowora A. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. Ibadan, Nigerian: Spectrum Books Ltd., 1993.289 p.
  10. Association of Official Analytical Chemist (AOAC). Official Methods of Analysis. Washington DC, United States: Association of Official Analytical Chemists, 1990; P. 20-26.
  11. Sharma SR, Dwivedi SK, Swarup D. Hypoglycemic antihyperglycemic and hypolipidemic activities of Cesalphinia bounducella seed in rats. J Ethnopharmacol. 1997;58(1):39-44. PubMed, CrossRef
  12. Kjellén L, Bielefeld D, Hook M. Reduced sulfation of liver heparan sulfate in experimentally diabetic rats. Diabetes. 1983;32(4):337-342. PubMed, CrossRef
  13. Kingsley O, Marshall AA. Medicinal potential of Acalypha wilkesiana Leaves. Adv Res. 2014;2(11):655-665. CrossRef
  14. Tuso PJ, Ismail MH, Ha BP, Bartolotto C. Nutritional update for physicians: plant-based diets. Perm J. 2013;17(2):61-66. PubMed, PubMedCentral, CrossRef
  15. Mohan Y, Jesuthankaraj GN, Thangavelu NR. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013: Article ID 716073. PubMed, PubMedCentral, CrossRef
  16. Hamid RHM, Hamid RE. Screening of bile acid binding capacity of some synthetic dietary fiber. Global Veterinaria. 2013; 10(4) 485-490. CrossRef
  17. Katsuren K, Tamura T, Arashiro R, Takata K, Matsuura T, Niikawa N, Ohta T. Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia. Biochim Biophys Acta. 2001;1531(3):230-240.  PubMed, CrossRef
  18. Duwaerts CC, Maher JJ. Macronutrients and adipose-liver axis in obesity and fatty liver. Cell Mol Gastroenterol Hepatol. 2019;7(4):749-761. PubMed, PubMedCentral, CrossRef
  19. Bao L, Hu L, Zang Y, Wang Yi. Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum. Exp Ther Med. 2016;11(4):1417-1424.  PubMed, PubMedCentral, CrossRef
  20.  Kawai Y, Sato-Ishida R, Motoyama A, Kajinami K. Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus. Drug Des Devel Ther. 2011;5:283-297. PubMed, PubMedCentral, CrossRef
  21. Golzarand M, Mirmiran P, Bahadoran Z, Alamdari S, Azizi F. Dietary phytochemical index and subsequent changes of lipid profile: A 3-year follow-up in Tehran Lipid and Glucose Study in Iran. ARYA Atheroscler. 2014; 10(4): 203-210.  PubMed, PubMedCentral

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