Ukr.Biochem.J. 2019; Volume 91, Issue 6, Nov-Dec, pp. 112-121


Corvitin modulates the content of lipids in rat liver bile

T. V. Vovkun1, P. I. Yanchuk1, L. Ya. Shtanova1,
S. P. Veselsky1, N. B. Filimonova1, I. V. Komarov2

1ESC “Institute of Biology and Мedicine”, National Taras Shevchenko University of Kyiv, Ukraine
2“Institute of High Technologies
”, National Taras Shevchenko University of Kyiv, Ukraine;

Received: 23 March 2019; Accepted: 18 October 2019

Quercetin (QUE) and its water-soluble form сorvitin are medicinally important members of the fla­vonoid family and the most prominent dietary antioxidants. Numerous pharmacological effects of quercetin include protection against diseases, such as atherosclerosis, myocardial infarction, and cerebrovascular disea­ses. Corvitin modulates liver blood flow but its effects on liver lipid metabolism have not been understood. We investigated the influence of corvitin (2.5, 5, 10 mg/kg) on the formation and secretion of cholesterol (Chol), cholesterol esters (EChol), phospholipids (PLs), free fatty acids (FFAs), and triglycerides (TGs) into the bile. Secreted bile was collected during 2.5 h of the experiment. Lipid fractions of the bile were separated by thin-layer chromatography. We defined that administration of corvitin caused a significant (P < 0.05–0.001) increase in levels of all studied lipid components of bile. At a dose of 2.5 and 5 mg/kg corvitin increased bile content of Chol, PLs and FFAs,and at a  dose of 10 mg/kg had the largest effect on the total production of EChol and TGs. We concluded that corvitin activates the liver lipids metabolism and processes of bile formation.

Keywords: , , , , , , ,


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