Ukr.Biochem.J. 2014; Volume 86, Issue 4, Jul-Aug, pp. 158-163

doi: http://dx.doi.org/10.15407/ubj86.04.158

Influence of semicarbazide on the peroxidation processes and Lewis carcinoma growth in mice

22.06.2015   Uncategorized   No comments

L. M. Petrun

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: petrun@biochem.kiev.ua

Effects of various doses of semicarbazide on Lewis carcinoma metastasing and peroxidation processes in С57В1 mice have been investigated. In the animals with inoculated Lewis carcinoma, the semicarbazide in the dose of 1/120 LD50 had practical influence on the tumour growth and inhibited the metastasing into mice lungs (P < 0.05). Importantly, this dose significantly inhibited the formation of free radicals and active forms of oxygen against the background of decrease of the aldehydes level that was related to the acceptor properties of the drug.

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References:

  1. Mäki JM, Sormunen R, Lippo S, Kaarteenaho-Wiik R, Soininen R, Myllyharju J. Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol. 2005 Oct;167(4):927-36. PubMed, PubMedCentral, CrossRef
  2. Maranghi F, Tassinari R, Marcoccia D, Altieri I, Catone T, De Angelis G, Testai E, Mastrangelo S, Evandri MG, Bolle P, Lorenzetti S. The food contaminant semicarbazide acts as an endocrine disrupter: Evidence from an integrated in vivo/in vitro approach. Chem Biol Interact. 2010 Jan 5;183(1):40-8. PubMed, CrossRef
  3. Dmytrenko MP, Shandrenko SG, Petrun LM, Kishko TO, Silonova NV, Latishko NV, Gudkova OO, Sushkova VV.  formaldehyde metabolism under semicarbazide intoxication. Ukr Biokhim Zhurn. 2010 Jul-Aug;82(4):86-91. Ukrainian. PubMed
  4. Grimsrud PA, Xie H, Griffin TJ, Bernlohr DA. Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem. 2008 Aug 8;283(32):21837-41.  Review. PubMed, PubMedCentral, CrossRef
  5. Morgan KT. A brief review of formaldehyde carcinogenesis in relation to rat nasal pathology and human health risk assessment. Toxicol Pathol. 1997 May-Jun;25(3):291-305. Review. PubMed, CrossRef
  6. Sherif HM. In search of a new therapeutic target for the treatment of genetically triggered thoracic aortic aneurysms and cardiovascular conditions: insights from human and animal lathyrism. Interact Cardiovasc Thorac Surg. 2010 Sep;11(3):271-6. Review. PubMed, CrossRef
  7.  Kinemuchi H, Sugimoto H, Obata T, Satoh N, Ueda S. Selective inhibitors of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) activity in mammalian tissues. Neurotoxicology. 2004 Jan;25(1-2):325-35. Review. PubMed, CrossRef
  8. Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006 Apr 27;440(7088):1222-6. PubMed, CrossRef
  9. Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 2009 Jan 6;15(1):35-44. PubMed, PubMedCentral, CrossRef
  10. Postovit LM, Abbott DE, Payne SL, Wheaton WW, Margaryan NV, Sullivan R, Jansen MK, Csiszar K, Hendrix MJ, Kirschmann DA. Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration. J Cell Biochem. 2008 Apr 1;103(5):1369-78. PubMed, CrossRef
  11. Garpenstrand H, Bergqvist M, Brattström D, Larsson A, Oreland L, Hesselius P, Wagenius G. Serum semicarbazide-sensitive amine oxidase (SSAO) activity correlates with VEGF in non-small-cell lung cancer patients. Med Oncol. 2004;21(3):241-50. PubMed, CrossRef
  12. Chirkin A. A. Practicum in Biochemistry. Minsk: Novoye znaniye, 2002. 512 p. (In Russian).
  13. Kozachenko AM, Rashba YuE, Vartanyan LS. New inhibitors of xanthine oxydase from the class of pyrazole(3,4-d-pyrimidines) and pyrazole(3,4-pyridines-pyrimidones): action mechanism of allopyrinol, its analogs. Khim. Pharmacol. Zhurn. 1982;(6):10–15. (In Russian).
  14. Moin VM. A simple and specific method for determining glutathione peroxidase activity in erythrocytes. Lab Delo. 1986;(12):724-7. Russian. PubMed
  15. Pushkina NN. Biochemical Methods of Research. Moscow: Medgiz, 1983. 395 p. (In Russian).
  16. Kallen RG. The mechanism of reactions involving Schiff base intermediates. Thiazolidine formation from L-cysteine and formaldehyde. J Am Chem Soc. 1971 Nov;93(23):6236-48. PubMed, CrossRef
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