Ukr.Biochem.J. 2012; Volume 84, Issue 1, Jan-Feb, pp. 79-84

Carbohydrate and nitrogenous metabolism condition in the rat tissue under experimental rhabdomyolysis

P. A. Kaliman, S. M. Okhrimenko

Karazin Kharkiv National University, Ukraine;

Some effects of glycerol injection on indices of the condition of the thiol-disulfide system as well as carbohydrate and nitrogen metabolism in rats in vivo were studied. A decrease was revealed in levels of non-protein SH-groups in the liver, kidney and heart, as well as of protein SH-groups in the kidney and heart of rats following glycerol injection. That might be connected with SH-group oxidation under the excessive arrival of free haem into tissues under rhabdomyolysis. A decrease in glycogen and  increase in tyrosine aminotransferase activity in the liver were observed. Activation of nitrogenous metabolism following glycerol injection is indicated by the increase of aminotransferase activity in organs, and concentration of blood urea. High concentration of creatinine in the rat serum can reflect malfiltration in kidneys.

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