Ukr.Biochem.J. 2020; Volume 92, Issue 5, Sep-Oct, pp. 78-86

doi: https://doi.org/10.15407/ubj92.05.078

Effects of ethylthiosulfanylate and chromium (VI) on the state of pro/antioxidant system in rat liver

09.11.2020   Uncategorized   No comments

B. І. Kotyk1, R. Ya. Iskra1, O. M. Slivinska1, N. M. Liubas1,
A. Z. Pylypets1, V. I. Lubenets2, V. I. Pryimych3

1Institute of Animal Biology, NAAS of Ukraine, Lviv;
2Lviv Polytechnic National University, Ukraine;
3Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Ukraine;
e-mail: kicyniabo@gmail.com

Received: 04 April 2020; Accepted: 25 June 2020

Ethylthiosulfanylate is alkyl ester of thiosulfoacid and belongs to the class of thiosulfonate compounds. Structurally, thiosulfonates are synthetic analogues of natural phytoncides. It is known that, natural organic sulfur-containing compounds are characterized by antioxidant and detoxification properties against heavy metals toxicity. Therefore, the purpose of the study was to investigate the influence of ethylthiosulfanylate, as a synthetic analogue of natural phytoncides, on the state of the pro/antioxidant system in the liver of laboratory rats exposed to Cr(VI). It was found that ethylthiosulfanylate exposure at a dose 100 mg/kg body weight daily for 14 days led to a decrease in the intensity of increasing of the lipid hydroperoxides (LHP) content in the rat liver caused by Cr(VI) action. In addition, ethylthiosulfanylate pretreatment prevented depletion of reduced glutathione (GSH) pool under the action of potassium dichromate oxidative stress and performed the accumulation of cellular GSH in rat liver.

Keywords: , , , , , ,

References:

  1. Xu J, Zhao M, Pei L, Zhang R, Liu X, Wei L, Yang M, Xu Q. Oxidative stress and DNA damage in a long-term hexavalent chromium-exposed population in North China: a cross-sectional study. BMJ Open. 2018;8(6):e021470. PubMed, PubMedCentral, CrossRef
  2. Abu Zeid EH, Hussein MMA, Ali H. Ascorbic acid protects male rat brain from oral potassium dichromate-induced oxdative DNA damage and apoptotic changes: the expression patterns of caspase-3, P 53, Bax, and Bcl-2 genes. Environ Sci Pollut Res Int. 2018;25(13):13056-13066. PubMed, CrossRef
  3. Banerjee S, Joshi N, Mukherjee R, Singh PK, Baxi D, Ramachandran AV. Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage. Interdiscip Toxicol. 2017;10(1):20-29. PubMed, PubMedCentral, CrossRef
  4. Boşgelmez Iİ, Güvendik G. N-Acetyl-L-cysteine protects liver and kidney against chromium(VI)-induced oxidative stress in mice. Biol Trace Elem Res. 2017;178(1):44-53. PubMed, CrossRef
  5. Patlolla AK, Barnes C, Yedjou C, Velma VR, Tchounwou PB. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol. 2009;24(1):66-73. PubMed, PubMedCentral, CrossRef
  6. Mary Momo CM, Ferdinand N, Omer Bebe NK, Alexane Marquise MN, Augustave K, Bertin Narcisse V, Herve T, Joseph T. Oxidative effects of potassium dichromate on biochemical, hematological characteristics, and hormonal levels in rabbit doe (Oryctolagus cuniculus). Vet Sci. 201918;6(1):30. PubMed, PubMedCentral, CrossRef
  7. Ola-Davies OE, Oyagbemi AA, Omobowale TO, Akande I, Ashafa A. Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling. J Basic Clin Physiol Pharmacol. 2019;30(4): 1-21. PubMed, CrossRef
  8. Pylypets AZ, Iskra RYa, Havryliak VV, Nakonechna AV, Novikov VP, Lubenets VI. Effects of thiosulfonates on the lipid composition of rat tissues. Ukr Biochem J. 2017;89(6): 56-62. CrossRef
  9. Lubenets V, Stadnytska N, Baranovych D, Vasylyuk S, Karpenko O, Havryliak V, Novikov V. Thiosulfonates: The Prospective Substances against Fungal Infections. Fungal Infection. 2019; 1-24. CrossRef
  10.  Manoj Kumar V,  Henley AK, Nelson CJ, Indumati O, Prabhakara Rao Y, Rajanna S, Rajanna B. Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney. Environ Sci Pollut Res Int. 2017;24(2):1544-1552. PubMed, CrossRef
  11. Yousef AE, El Hakeim TA, Thakeb MM. The antioxidant effect of garlic powder on rats treated by different doses of chromium chloride. Egypt J Chem Environ Health. 2015;1(1):379-388.
  12. Lubenets VI, Havryliak VV, Pylypets AZ, Nakonechna AV. Changes in the spectrum of proteins and phospholipids in tissues of rats exposed to thiosulfonates. Regul Mech Biosyst. 2018;9(4):495-500. CrossRef
  13. Smith M, Hunter R, Stellenboom N, Kusza DA, Parker MI, Hammouda ANH, Jackson G, Kaschula CH. The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS. Biochim Biophys Acta. 2016;1860(7):1439-1449. PubMed,  CrossRef
  14. Baseggio Conrado A, Capuozzo E, Mosca L, Francioso A, Fontana M. Thiotaurine: From Chemical and Biological Properties to Role in H2S Signaling. Adv Exp Med Biol. 2019;1155:755-771. PubMed, CrossRef
  15. Vezza T, Algieri F, Garrido-Mesa J, Utrilla MP, Rodríguez-Cabezas ME, Baños A, Guillamón E, García F, Rodríguez-Nogales A, Gálvez J. The immunomodulatory properties of propyl-propane thiosulfonate contribute to its intestinal anti-inflammatory effect in experimental colitis. Mol Nutr Food Res. 2019;63(5):e1800653. PubMed, CrossRef
  16. Bashandy SAE, Amin MM, Morsy FA, El-Marasy SA. Amelioration of the nephrotoxic effect of potassium dichromate by whey protein and/or nigella sativa oil in male albino rats. J Appl Pharm Sci. 2016;6(8): 044-050. CrossRef
  17. Lubenets VI. Thiosulfonates: synthesis and properties. Ukr Chem J. 2003;69(3):109-117. (In Ukrainian).
  18. Mladenov M, Gokik M, Hadzi-Petrushev N, Gjorgoski I, Jankulovski N. The relationship between antioxidant enzymes and lipid peroxidation in senescent rat erythrocytes. Physiol Res. 2015;64(6):891-896. PubMed, CrossRef
  19. Vlizlo VV, Fedoruk RS, Ratych IB. Laboratory methods of research in biology, animal husbandry and veterinary medicine. Lviv: Spolom. 2012. 764 p. (In Ukrainian).
  20. Ambrogi V, Carfagna C, Cerruti P, Marturano V. Additives in Polymers. Modification of Polymer Properties. 2017; 87-108.  CrossRef
  21. Chauvin JR, Griesser M,  Pratt DA. The antioxidant activity of polysulfides: it’s radical! Chem Sci. 2019;10(19):4999-5010. PubMed, PubMedCentral, CrossRef
  22. Onul N, Ertik O, Mermer N, Yanardag R. Synthesis and biological evaluation of S-substituted perhalo-2-nitrobuta-1,3-dienes as novel xanthine oxidase, tyrosinase, elastase, and neuraminidase inhibitors. J Chem. 2018;2018:1-11. CrossRef
  23. Touihri I, Boukhris M, Marrakchi N, Luis J, Hanchi B, Kallech-Ziri O. Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil. J Oleo Sci. 2015;64(8):869-879. PubMed, CrossRef
  24. Yaremkevych H, Polischuk I, Mandzynets S, Bura M, Sanagurskyi D, Lubenec V, Novikov V. Analysis of variance of influence of thiosulphonic acidderivatives on the Nа+, K+-ATP-ase activity of loachembryos in vitro. Visnyk Lviv Univ Ser Biol. 2011;(57):38–46. (In Ukrainian).
  25. Mehta SK, Gowder GT. Members of Antioxidant Machinery and Their Functions. Basic Principles and Clinical Significance of Oxidative Stress. 2015; 59-85. CrossRef
  26.  Vavilin V. A., Shintyapina A. B., Safronova O. G. Position of an Active Thiosulfonate Group in New Phenolic Antioxidants is Critical for ARE-Mediated Induction of GSTP1 and NQO1. J Pharm Sci Res. 2014; 6(4):178-183.
  27. Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L. L-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315-328. PubMed, CrossRef
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